Unchained Labs

Uncage biologics characterisation with problem-tackling solutions for measuring protein concentration, stability, aggregation and viscosity.

• Stability and formulation screening
• Protein quantification
• Quantification & aggregation
• Buffer exchange & sample preparation
• Viscosity

Unlock viral vectors with solutions designed to streamline workflows and accelerate gene therapy development.

• Titre & empty/full ratio
• AAV capsid stability
• Adenovirus titre empty/full ratio
• Lentivirus titre and structure
• Nucleic acid quantification

Beef up lentiviral characterisation with a single solution

• Lentivirus titre and structure

Leprechaun is the only system that measures lentiviral titre by confirming if the particles are the right size, have the right structure and have RNA on board – on crude or pure samples. It uses this info to tell the difference between a virus with all the right parts and particles that are missing VSVG or p24. Leprechaun also measures contaminating particles like extracellular vesicles (EVs) and differentiates viral p24 from soluble p24. This means researchers will finally know exactly what’s in their sample.

Accelerate lipid and other therapeutic nanoparticle characterisation, formulation screening, optimisation and GMP manufacture with Unchained Labs’ solutions.

• LNP formulation
• LNP optimisation
• GMP LNP production
• Nanoparticle concentration and sizing
• Payload quantification
• Nucleic acid quantification

Get fast and accurate quantification and quality measurements on DNA, RNA and nucleic acids.

• Nucleic acid quantification
• Extraction and purification QC

Biologics & gene therapy

• Formulation and developability
• Sample preparation and liquid handling

Small molecules

• Reaction screening
• Reaction optimisation
• Formulation and polymorph screening
• Powder dispensing

Polymers & catalysts

• Polymerisation optimisation
• Catalyst screening
• Powder dispensing